Neural Cell Adhesion Molecule 2 and synapses

Earlier this year, scientists at the University of New South Wales  reported investigating the Neural Cell Adhesion Molecule 2 (NCAM2), linked to autism, Downs.   The team found that NCAM2 clusters were associated with Calcium-ion signaling and associated molecules.     Now, they report low levels of NCAM2 in the hippocampus of patients with Alzheimer’s, suggesting beta-amyloid toxicity leads to loss of NCAM2, which in turn leads to synapse loss. link